IN VITRO ACTIVITY OF CEPHALOSPORINS AGAINST MYCOBACTERIUM TUBERCULOSIS H37Rv: STRUCTURE-ACTIVITY RELATIONSHIPS
نویسندگان
چکیده
منابع مشابه
Structure-activity relationships of macrolides against Mycobacterium tuberculosis.
Existing 14, 15 and 16-membered macrolide antibiotics, while effective for other bacterial infections, including some mycobacteria, have not demonstrated significant efficacy in tuberculosis. Therefore an attempt was made to optimize this class for activity against Mycobacterium tuberculosis through semisyntheses and bioassay. Approximately 300 macrolides were synthesized and screened for anti-...
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Roxithromycin has recently been shown to possess significant in vitro activity against a variety of atypical mycobacteria such as the M. avium complex, M. scrofulaceum, M. szulgai, M. malmoense, M. xenopi, M. marinum, and M. kansasii and rare pathogens like M. chelonei and M. fortuitum. In the present investigation, screening of its in vitro activity was further extended by testing it against 3...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1973
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.26.737